Visual Discrimination Predicts Naming and Semantic Association Accuracy in Alzheimer Disease
نویسندگان
چکیده
منابع مشابه
Visual association pathology in preclinical Alzheimer disease.
The transition from normal aging to mild cognitive impairment to Alzheimer disease (AD) is often indistinct. Imaging studies suggest early changes in posterior brain regions, including posterior temporoparietal and occipital cortex, but pathologic studies show initial changes in the medial temporal lobe with progressive neocortical involvement as cognition deteriorates. We evaluated the regiona...
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However, using a model restricted to elderly APOE 4 noncarriers, the association became somewhat stronger (SNP 8, p = 0.0163; SNP 24, p = 0.0375). More importantly, the associated variants in the study by Shibata et al. [1] were identical to those in the study by Rogaeva et al. [2] . For SNP 24, the T allele was associated with AD in Caucasians as well as in Japanese people. For SNP 8, the C al...
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The genetics of Alzheimer disease (AD) to date support an age-dependent dichotomous model whereby earlier age of disease onset (< 60 years) is explained by 3 fully penetrant genes (APP [NCBI Entrez gene 351], PSEN1 [NCBI Entrez gene 5663], and PSEN2 [NCBI Entrez gene 5664]), whereas later age of disease onset (> or = 65 years) representing most cases of AD has yet to be explained by a purely ge...
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ژورنال
عنوان ژورنال: Cognitive and Behavioral Neurology
سال: 2010
ISSN: 1543-3633
DOI: 10.1097/wnn.0b013e3181e61cf1